The new coronavirus survives 20 years at -20℃?

As the last month of the first half of 2020 draws to a close and summer looms, new and old rumors abound, most of which are being spun in the wake of coVID-19.

Today, WeChat has compiled an official list of the top 10 most widely circulated rumours among friends in June, seven of which were related to covid-19.

How many have you seen in your circle of friends?
How many times have you been hit?

  1. Spread of new Crown of imported seafood

Typical rumor sample

A source said, “The imported seafood infected with novel Coronavirus and then spread to the crowd in the farmers’ market”.

The truth:

According to Li Fengqin, director of the microbiology laboratory of the National Center for Food Safety Risk Assessment, any food, including seafood, will not get infected with avirus, but there is the possibility of contamination from a novel Coronavirus.
The customs now tests every batch of imported food.

If you are not sure, you can cook the food thoroughly and thoroughly, and thoroughly heat it to kill all the microorganisms.
In addition, processing and storage of food should be raw and cooked separately to prevent cross contamination.

Novel coronavirus can live for 20 years

Typical rumor sample

Recently, a report entitled “Novel Coronavirus will live for 20 years at minus 20℃” was widely forwarded. It said, “Novel Coronavirus will live for 20 years at minus 20℃”.

The truth:

In fact, Prof. Li did not specifically refer to novel Coronavirus in terms of the viral life time, but to “common situation” and “known virus”. Some media misinterpreted the virus and thus caused misinterpretation.

  1. Mount Wutai does not receive tourists from Beijing and Hebei

Typical rumor sample

On June 19, many netizens forwarded the message that “Due to the impact of the epidemic, Mount Wutai currently does not receive tourists from medium and high-risk areas (Beijing, Northeast, Hubei and Hebei)”. The message also published the office phone number of the company and signed the name of The Mount Wutai Visitor Center.

The truth:

According to the Tourist Service Center of Wutai Mountain scenic Area, there is no such thing as not receiving tourists from Beijing, northeast China, Hubei and Hebei.

  1. Drinking white wine can fight cancer

Typical rumor sample

Online articles claiming that “baijiu is a cancer killer” have been forwarded by a large number of netizens every year.
Transmission has been rising again recently.

The truth:

As early as 1988, the World Health Organization’s Cancer Research Department concluded that alcohol is a carcinogen and a major cause of human cancer.

  1. There are coVID-19 contaminants in foreign parcels

Typical rumor sample

“Do not accept express parcels from unknown sources, especially those abroad, which may be contaminated by patients with COVID-19,” and “such cases have occurred in China.”

The truth:

There have been no reports of coVID-19 infections from receiving deliveries.
Foreign parcels entering China are rigorously screened and heavily disinfected by customs.

6, AIDS blood drops into the food caused many people to become infected

Typical rumor sample

Recently, a so-called “emergency notice” went viral: “Someone has dropped the blood of an HIV infected person into food, and many people have become infected.”

The truth:

The situation in which rumors spread without any occurrence of rumors.
Experts have repeatedly made it clear that food does not transmit HIV.

In fact, since 2012, this kind of rumor has come out from time to time to “slander” a kind of food, such as chicken, barbecue, salad, cherry, watermelon and so on have been lying on the gun, and can make people enjoy a good meal.

  1. Novel coronavirus is transmitted by mosquitoes

Typical rumor sample

Recently, there was a rumor on the Internet that “Novel Coronavirus is spreading through mosquitoes”.

The truth:

According to the China Center for Disease Control and Prevention, no novel coronavirus infection has been found in humans worldwide.

8, hot water can be forced to go deep into the bone marrow of the cold

Typical rumor sample

After summer began, people often forwarded messages on Wechat moments saying, “Drinking hot water in the summer can force the cold air deep into the bone marrow, so as not to get too cold in winter.”

The truth:

It is an exaggeration to say that drinking hot water can drive out the chill that has been building up in the bone marrow for years.

  1. Express delivery to Beijing is suspended

Typical rumor sample

Recently, a news that some express delivery companies have suspended shipments to Beijing due to the epidemic has circulated on the Internet.

The truth:

It has been verified that the postal service, SF Express and other logistics companies have never issued a similar notice. At present, express delivery flowing from Beijing can still be accepted as normal.
However, some parcels may be affected due to the upgrading of control measures in some regions in Beijing.

Tens of thousands of people in Beijing’s Xinfadi were transported to Tangshan in Hebei province for quarantine

Typical rumor sample

“Hundreds of buses are pulling tens of thousands of people from the Xinfadi market to Tangshan for quarantine.”

The truth:

According to the official weibo account, from June 14, nearly 10,000 operators, purchasers and workers in the Wholesale market in Xinfai will collect throat swabs and then be transported by bus to observation points in Fengtai, Changping, Fangshan, Tongzhou, Daxing and the Economic development Zone for observation.

What benefits does vitamin E have to the man?

In modern society, more and more people start to keep in good health when they are young, reasonable collocation of diet, pay attention to food calories, ensure the intake of daily vitamins, hoping that they can not only have a beautiful appearance, but also have a more healthy body.
Among all kinds of vitamins, one of the most indispensable is vitamin E.

Vitamin E helps men prevent many diseases. What are the specific benefits?
To sum up, there are mainly four points.

One, prevent arteriosclerosis.
Too much cholesterol in the blood can stick to the walls of blood vessels, narrowing arteries and delivering less blood and oxygen to the heart.
As an antioxidant, vitamin E is fat-soluble, which can effectively prevent atherosclerosis and protect the health of cardiovascular system.
Men are three times more likely to die of heart disease in their 40s than women.
Therefore, men should pay attention to the daily supplement of vitamin E.

Second, slow down the aging rate.
Most men live less elaborate lives than women and don’t pay much attention to sun protection, hydration, hydration and repair, which is why they look older than their years.
If your male friends feel that their daily skin care routine is too tedious and they want to stave off aging, try vitamin E supplements.
Vitamin E can promote the aggregation of protein cells after entering the human body, accelerate the generation of collagen white, increase the elasticity of the skin, but also promote metabolism, prevent the generation of senile plaques.

Third, maintain reproductive function.
Taking vitamin E appropriately for men can promote the secretion of sex hormones, improve fertility, greatly increase the number and quality of sperm, strengthen sperm and kidney, enhance Yang and qi, and effectively prevent testicular atrophy and infertility.
Tocopherol, nicknamed for its role in maintaining reproductive function, has been shown in animal clinical studies to lead to genital damage, poor fertility and recurrent miscarriage.

Fourth, improve resistance.
Many people are weak and sick because of their low resistance.
Vitamin E supplements can help increase the activity of lymphocytes in the body, reduce the risk of infection, strengthen the immune system, and help prevent and treat scurvy, colds, and bleeding gums.
Vitamin E also helps to prevent the formation of carcinogens nitrosamines, has a certain anticancer effect.
For men, vitamin E supplementation is also a good way to strengthen the body and improve health.

Vitamin E is both natural and synthetic.
Natural vitamin E is safer and more absorbent than synthetic vitamin E, so try to eat foods rich in vitamin E, such as corn, cabbage, spinach, kiwi, eggs and beans.
After all, “it’s poison”, can be from vegetables and fruits intake to avoid drug supplements.

It is important to note that taking care of your body is a slow process, and it is important not to rush into it.
Adult men need about 14 milligrams of vitamin E a day, and the recommended daily intake is about 100 milligrams. Too much vitamin E can trigger toxicity, causing dizziness, high blood pressure, nausea and diarrhea.
Therefore, it is important to be very careful when taking synthetic vitamin E, so as not to make the supplement fatal.

A Chinese study reveals the dynamics of how a single Ebola virus enters cells

Chinese researchers used techniques such as single particle force tracing to reveal the dynamic process and dynamic mechanism of a single Ebola virus invading cells in real time.
The relevant findings are of great significance for the in-depth understanding of the mechanism of Ebola virus infection, and also provide an important reference for the development of antiviral pathways.

Ebola is one of the most deadly pathogens to humans, causing severe hemorrhagic fever with a fatality rate of up to 90%.
Cui Zongqiang, a researcher from Wuhan Institute of Virology, Chinese Academy of Sciences, collaborated with Shan Yoping, a professor from Changchun University of Technology, and Shi Xinghua, a researcher from the National Center for Nanoscience and Biotechnology, to conduct a study on a single Ebola virus invading cells.

The researchers first constructed and fluorescently labeled filamentous Ebola-like particles.
The filamentous Ebola-like particle has the same ability to invade as the wild Ebola-like virus, but it has no viral nucleic acid inside and cannot replicate.
Using techniques such as single-particle force tracer, dynamic simulation and single-particle fluorescence tracer, the researchers traced the dynamic process of a single Ebola-like particle entering cells and analyzed its dynamic mechanism.

This study revealed that the filamentous Ebola-like particles entered the cells in horizontal or vertical modes, as well as the corresponding fine mechanisms such as space-time, energy, interaction mode with the receptor and invasion pathway, and visually confirmed that the filamentous Ebola-like particles entered the cells in the giant pinocytosis pathway.

At present, the related research results have been published online in the international academic journal “American Chemical Society nano”.

Suppressing the immune system could save the lives of patients with severe COVID-19

An Oxford-led trial testing a common immunosuppressive drug used by coVID-19 patients has found that the use of the cheap steroid for seriously ill patients in intensive care can significantly reduce mortality.
This study suggests that providing immunosuppressive drugs at the right time can improve survival in patients with advanced COVID-19.

Dexamethasone was first developed in the 1950s as part of the first anti-inflammatory drugs that revolutionized medicine.
Dexamethasone is an immunosuppressant commonly used to treat acute allergic reactions, skin diseases and asthma.

While it may seem counterintuitive that suppressing the body’s natural defenses can help people survive a deadly viral infection, it’s not unprecedented that this approach has been used to save lives in virus-caused pneumonia.

While this medical use of corticosteroids remains controversial, some data from the H1N1 swine flu outbreak suggest it may help patients with severe viral pneumonia.

Doctors soon began to notice in the early stages of the current pandemic that patients who usually die of COVID-19 have a disease called acute respiratory distress syndrome (ARDS).
When the body’s natural immune defenses overreact, the lungs become inflamed, leading to respiratory failure and death.
David Gaze of the University of Westminster explained that in the case of COVID-19, this may be caused by an immune response called cytokine storm.

In early March, Oxford University launched a series of large randomized controlled trials called RECOVERY (Randomised Evaluation of CoVID-19 thERapY).
The purpose of the trial is to explore whether existing drugs or treatments can be effectively re-used for COVID-19 treatment.
RECOVERY initially explored six different treatments, including azithromycin, a common antibiotic, dexamethasone and hydroxychloroquine.

The hydroxychloroquine trial was recently halted due to a lack of efficacy after the steering committee reviewed the results of an ongoing trial involving more than 1,500 patients on treatment.
Some trials of dexamethasone have also recently been halted for the exact opposite reason – the drug has shown clear clinical success.

The full data for the trial have not yet been published in a peer-reviewed journal, but the researchers have published them in a preprint article.
The results showed that 2,104 patients with severe COVID-19 received a small dose of dexamethasone for 10 days, while 4,321 in the control group received standard treatment.

The results showed that in intensive care patients treated with oxygen, corticosteroids reduced mortality by about 20 percent compared with the control group.
For those on ventilators, the results were even more dramatic, with a 30 per cent reduction in mortality.

More importantly, the study also showed no benefit for patients who did not need breathing support.
This confirms that immunosuppressive therapy should only be used in patients with severe life-threatening stage.

Martin Landray, one of the lead investigators on the trial, said the data were clear and could be immediately used by intensive care doctors around the world.

Simon Maxwell, an independent clinical pharmacologist from the University of Edinburgh, said the RECOVERY trial confirmed the importance of carefully controlled randomized clinical studies that will help doctors from around the world find the best treatment for COVID-19 patients.
“This is the first major breakthrough in the treatment of COVID-19 infection,” said Maxwell.
It demonstrates the efficacy of a simple, inexpensive, familiar and widely successful treatment for those most seriously ill.
Although many units are already being treated with corticosteroids, these results give confidence.”

Tocilizumab, another immunosuppressive therapy used to treat patients with severe COVID-19, has shown beneficial early data.
Tozumab is a very different drug from dexamethasone.
As opposed to the immunosuppressive effects of corticosteroids like dexamethasone, tozumab is a monoclonal antibody designed to block the activity of a cytokine called Interleukin 6 (IL-6) immune cells.

A Yale University study showed that tozumab had a similar overall mortality benefit to dexamethasone in severely ill COVID-19 patients, though unlike the RECOVERY trial, there was no randomized controlled component.

However, these results provide encouraging evidence that the risk of death from COVID-19 can be reduced if immunosuppressive drugs are used when appropriate.
However, this new redesign of existing treatments will only help those with the most severe form of COVID-19.
As Devi Sridhar of Edinburgh University puts it, “the real game changer will be a drug and vaccine that prevents people from going from mild to severe symptoms.”

There was some good news about the coVID-19 vaccine

China biological new crown inactivated international clinical phase iii launching ceremony held in the form of video conference, the three sides: Beijing, China, wuhan, the united Arab emirates, ABU dhabi, in the meeting, China the united Arab emirates (uae) signed a cooperation agreement, the united Arab emirates (uae) health minister presented China with a clinical trial license file, marking the world’s first new crown inactivated international launched the third phase of clinical trial.

Just a few days ago, WHO chief scientist Sumiya Swaminathan told reporters that nearly 200 coVID-19 vaccines were under development, 10 were in the final stages of phase II testing and four were on the way to phase III clinical trials.
Swaminathan explained that the third stage is the last stage before mass production.

It will take a long time for vaccines to be developed, tested and mass-produced, swaminathan said, but because of the severity of the global epidemic, research institutions will have to speed up the process, and because of scientists’ efforts, one or two vaccines could be ready by the end of the year.
If the vaccine is successfully developed and proves effective, mass production could begin, with nearly 2 billion doses expected by 2021.
The rapid production of the vaccine is not guaranteed to be safe, but because the vaccine will be tested on thousands of patients during development to ensure it has no side effects in humans, trials of this scale are sufficient, but “risk free” is unlikely.

Zhong said at the end of May that China’s vaccine research progress is in the first tier in the world, and we will not lag behind other countries.
In early June, zhong said in a live television, natural immune is 60-70% of the population is infected with a country, killing tens of millions of people, the price is too big, so the best way to solve the problem still have to rely on a large-scale vaccination, the vaccine is the main way to solve the herd immunity, the new crown vaccine can be used at the end of this fall or emergency at the earliest.

Jokic novel Coronavirus tested positive and treatment program postponed

Famous NBA reporter Woj revealed that Jokic was diagnosed

On June 24, ACCORDING to the media in the United States, Nikolai Jokic, a Serbian basketball star and NBA Denver nuggets player, had tested positive for avirus and was undergoing treatment in isolation in Serbia.

On the same day, tennis star Djokovic, also from Serbia, was diagnosed with avirus from novel Coronavirus.
Both had recently attended a charity tennis match in Belgrade, The Serbian capital, and had been in close contact, without wearing masks.
However, it is not clear that there is a direct correlation between almost simultaneous diagnosis.
Novel Coronavirus infected with the virus that infected a number of participating tennis stars and sports stars in a charity tennis show held by Djokovic is reported to have caused a public apology by Djokovic after his diagnosis.

According to the NBA rematch plan, foreign players currently abroad must report back to their teams and be tested by Coronavirus on June 15.
Jokic has taken a leave of absence from the team to postpone his return to the United States.
According to the Alliance, Jokic must return from Serbia to the United States after two novel Coronavirus tests were negative 24 hours apart.
When he arrived in Denver, he had to be tested again for the virus.

In the regular season, Jokic averaged 20.2 points, 10.2 rebounds, 6.9 assists, 1.2 steals and 0.7 blocks in 32.3 minutes.
The Nuggets are 43-22, third in the Western Conference behind the Lakers and clippers.
Jokic lost 40 pounds during NBA suspension and appeared ready to play again, but was diagnosed with avirus that could affect the Nuggets’ encore plans.
In addition to Jokic, Nuggets coach Michael Malone previously revealed that he was infected with avirus from novel Coronavirus.

The joint is indolent, did rheumatoid arthritis cure?

How to judge condition of rheumatoid arthritis stability is not repeated?
Just meet these three conditions!

Rheumatoid arthritis, once known as the “cancer of immortality,” this statement undoubtedly shows that rheumatoid arthritis causes severe physical and mental damage to patients, its harm is no less than cancer.

In daily life, there are a lot of rheumatoid arthritis patients feel joint pain relief or no pain, rheumatoid arthritis is cured, in fact this view is not comprehensive.

First of all, rheumatoid arthritis can not be cured at present, so can only be the maximum extent of the disease control in a stable period, and not a thorough cure.

Furthermore, to judge whether the condition of rheumatoid arthritis is stable or not, these three conditions should be met:

Basic conditions: Improved joint symptoms

If the patient has a sustained reduction in joint swelling and pain, a shortened morning stiffness, and a gradual return to range of motion, this means that the rheumatoid arthritis is improving, but not meeting the requirements for stability.

If the patient’s joints do not have obvious swelling and stiffness in the morning, they can wash, wear and take off clothes, walk and other basic activities, which reaches the primary condition of stable condition.

But that’s the bottom line, and the patient must continue taking the medication.

Key condition: Decreased inflammatory markers

At present, erythrocyte sedimentation rate (ESR) and C-reactive protein (CRP) are the main inflammatory markers to determine the severity of rheumatoid arthritis.

Generally speaking, the heavier the joint symptoms, the higher the inflammatory indicators, and the more obvious the improvement of joint symptoms, the greater the decrease of erythrocyte sedimentation rate and C-reactive protein level.

Clinically, some patients showed significant improvement in self-induced joint symptoms, or even no joint discomfort symptoms, but the level of erythrocyte sedimentation rate and C-reactive protein was still high or only slightly decreased.
This may be related to the temporary use of drugs (e.g. hormones, biological agents, etc.) that act quickly and have obvious effects.

Therefore, the current improvement in joint symptoms is temporary and can easily be repeated.

The condition is stable only when the patient has no obvious joint discomfort for a long time, and the erythrocyte sedimentation rate and C-reactive protein level are normal or nearly normal.

If you meet the “basic conditions + key conditions”, does that mean that rheumatoid arthritis long-term stability is not repeated?

No, there is a third condition.

Ideal condition: Imaging improvement

We know that the main pathological change of rheumatoid arthritis is synovitis, synovial dysplasia is the culprit leading to joint lesions, all the drugs on the treatment is also to minimize and inhibit synovial hyperplasia.

Joint symptoms improved, inflammatory indicators decreased, synovial hyperplasia will be reduced, but the reduction does not mean that there is no hyperplasia.

In fact, at this point, many patients are still in the state of mild synovial hyperplasia, but has not been able to cause joint symptoms and inflammatory indicators of abnormalities, which is the cause of the disease again and again.

Clinically, joint ultrasound, mri and other examination methods are generally used to check synovial hyperplasia and make the next treatment plan according to the degree of synovial hyperplasia.

However, in terms of the current medical level and treatment status, it is still difficult for the vast majority of rheumatoid arthritis patients to achieve imaging improvement.

Of course, rheumatoid arthritis treatment should not be erratic until doctors assess whether the condition is stable.
After the diagnosis of rheumatoid arthritis regardless of the severity of symptoms, should be treated to the hospital in a timely manner, at the same time, the patient should be tailored according to their own conditions, using different drugs, medication, drug withdrawal should be under the guidance of the doctor, the patient can not because of no pain and swelling, the symptoms are relatively light, without authorization to reduce drug withdrawal, self-determination.

Because unauthorized withdrawal may cause these symptoms:

  1. Rebound phenomenon: Some patients have been taking hormone drugs for a long time, and their condition has been completely alleviated. If the drug is suddenly stopped or the dosage is reduced too much or too fast at this time, the original disease may relapse or worsen.
  2. Withdrawal syndrome: During the withdrawal process, patients may experience severe fatigue, joint muscle pain, low mood, lack of food and drink, and even nausea and vomiting. A few patients may also experience collapse.

In addition, in medication process, want to measure liver function, blood to wait for index regularly, in medication initial stage, disease activity period reexamines can be a bit more often, after the condition is stable, every 2 ~ 3 months check can.

Masks, epidemic guns, vaccines, the next coVID-19 market coming out!

Just as pharmaceutical companies in the United States, Europe, China and other regions are racing to develop vaccines around the world, and the new vaccine is about to be mass produced, there is a shortage of small glass bottles for vaccines.
Schott, one of the world’s largest medical glass producers, recently said it had received orders for 1 billion vials this year, double its annual production capacity.
In order to mass produce the new crown vaccine, Johnson & Johnson alone purchased 250 million vials; a global NGO even purchased its own glass production line to ensure vaccine reserves.
According to the CEO of Tarant, a drug development solution and supplier of drugs, biological agents and health care products, the global new crown vaccine R & D company has entered vaccine R & D, making medical glass vials in short supply.
According to foreign media reports, the shortage of medical bottles is mainly due to the limited reserve of special materials for production. In general, the glass used to hold the vials contains certain chemicals that are resistant to extreme temperature changes and keep the vaccine stable. It takes days or weeks to process special glass into glass vials. The raw materials need to be melted first, then shaped into slender tubes, and finally the small tubes become small glass tubes.
In the process of blowing, the hottest part is easy to escape sodium borate. After cooling, boron will coagulate irregularly at the bottom and neck of the inner wall of the glass bottle. If the vaccine liquid is added, boron may dissolve into the liquid. The inner part of the glass bottle will also be corroded, and the metal will be dissolved, forming a corrosion layer on the glass surface.
If the tablet is injected into the human body, it may cause adverse reactions, so special personnel are required to check the tablet in the bottle.
(drawing pipe process, source: official account of all things)
As a result, glass vials take a long time to make, but when demand suddenly increases, there will be a short-term imbalance between supply and demand – just like masks and upstream melt blown cloths at the beginning of the year.
List of a shares
At present, the mainstream injection packaging material in the world is borosilicate glass, with the use ratio of more than 70%. But in China, it’s less than 10%. Since 2017, the State Food and drug administration has recommended the use of borosilicate glass as the injection packaging material. In 2019, the drug regulatory bureau issued another document to stipulate that the packaging materials used for domestic generic drugs shall not be lower than the packaging materials standards of European and American countries.
This year, Chinese pharmaceutical companies are competing to develop new crown vaccines, which is expected to speed up the replacement of borosilicate glass bottles in China.
At present, there are more than 1500 companies engaged in pharmaceutical glass bottle packaging in China. However, there are not many companies with corresponding businesses in A-share market, mainly Shandong Pharmaceutical glass and Zhengchuan shares.
(picture source: enterprise inspection)
Shandong Pharmaceutical glass is the leading manufacturer of medical glass in China, mainly engaged in the research, development, production and sales of various pharmaceutical glass packaging products, including six series of molded bottles, brown bottles, ampoule bottles, control bottles, butyl rubber plugs, aluminum plastic caps, etc. The market share of the company’s molding bottles is more than 80%, and it is also one of the two domestic manufacturers with approval documents for neutral borosilicate molding bottle packaging materials.
Shandong Pharmaceutical glass has a capacity of about 200 million borosilicate moulded bottles, and a capacity of 687 million borosilicate controlled series bottles. According to last year’s annual report, the company’s model bottle series contributed 52% of its revenue. The proportion of export revenue is 31.5%.
(source: tonghuashun)
In the first quarter of this year, the company recorded revenue of 761 million yuan, a year-on-year increase of 6.98%; net profit of 136 million yuan, a year-on-year increase of 22.63%. The decline of the company’s revenue / net profit growth was mainly affected by the epidemic.
(source: tonghuashun Ifind)
But in terms of share price performance, the company has maintained stable growth since 2018. From 2018 to now, the company’s share price has increased by 341%. Despite the possible shortage of vaccine glass bottles, the company’s growth space and fundamentals are also favored by the market.
As of the latest, the market value of the company is 28.7 billion yuan, with a rolling P / E ratio of 59x.
(source: tonghuashun Ifind)
Zhengchuan Co., Ltd. is also mainly engaged in the research, development, production and sales of pharmaceutical packaging materials such as pharmaceutical glass control bottles. Its main products include borosilicate glass control bottles of different types and specifications, sodium calcium glass control bottles, etc.
In the first quarter of this year, the company achieved a total operating revenue of 145 million yuan, down 13.32% year-on-year; its net profit was 18.99 million yuan, down 18.67% year-on-year. In 2019, the company’s revenue and net profit also recorded a significant decline.
(source: tonghuashun Ifind)
In addition to the above two companies, Qibin group also announced the investment and construction of neutral borosilicate medical glass project at the end of last year. The project is planned to be constructed in stages, with a total investment of about 600 million yuan. The first phase of the project is planned to last 12 months and is under preparation.
There is a mask concept in front of the car. At present, the “scarce” medical glass bottle label in the A-share market is expected to take off if it meets the air outlet.
Warning of melt blown cloth
There is no doubt that the mask industry chain is the first industry benefiting from the “new crown market”.
However, after the whole industry entered the Bureau, there was overcapacity in the mask industry chain.
Recently, the head of the manufacturer of Guangdong mask factory revealed that the price of 95 grade meltblown cloth has dropped to 20000-30000 yuan per ton at present, while the price per ton in peak period once reached 700000 yuan. At the peak, the unit price per ton of materials once reached 700000 yuan. The related production equipment also decreased by the same extent, and the downstream demand for masks continued to shrink.
At the same time, Evonik technology, a listed company, has stopped orders for interface masks. Mask production, once seen as a “money printing business”, has finally faded out of sight.
In the stock market, the “mask concept stock”, which must have skyrocketed from February to March, has also experienced stock price correction in some stocks in the past month.
(source: tonghuashun Ifind)
Therefore, for the concept of medical glass, mask

Novartis anti-inflammatory drug Ilaris is approved by the US FDA: the first drug to treat adult Still’s disease (AOSD)!

The U.S. Food and Drug Administration (FDA) recently approved Novartis’ anti-inflammatory drug Ilaris (Elater, generic name: canakimumab, kanazumab) for the treatment of active Still’s disease, including Adult paroxysmal Still’s disease (AOSD). Previously, Ilaris has been granted priority review designation (PRD) for the treatment of Still’s disease.

It is worth mentioning that Ilaris is the first drug approved for the treatment of Still’s disease. Previously, Ilaris was also approved for the treatment of patients with systemic juvenile idiopathic arthritis (SJIA) aged ≥ 2 years.

Nikolay Nikolov, MD, acting director of the Department of Rheumatology and Transplantation Medicine at the FDA Center for Drug Evaluation and Research, said: “Before today’s approval, there is no FDA-approved treatment for patients with Still’s disease, which manifests as painful arthritis, fever and rash And other symptoms. Today’s approval provides these patients with the first treatment option.”

Adult-Onset Still’s Disease (AOSD) is a rare and serious autoimmune disease of unknown etiology. Autoimmune diseases are caused by abnormalities of the immune system. Such abnormalities can trigger an inflammatory response, thereby damaging the body’s own tissues. The characteristics of AOSD have considerable overlap with systemic juvenile idiopathic arthritis (SJIA), including elevated fever, arthritis, rash, and inflammation markers. The overlapping features of AOSD and SJIA indicate that this is a disease continuum, rather than two separate diseases.

Interleukin-1 (IL-1) is an important cytokine that regulates the body’s immune system, and its role in AOSD and SJIA has been confirmed. Ilaris works by blocking the action of IL-1 and inhibiting inflammation in patients with this autoimmune disease. The safety and effectiveness of Ilaris in the treatment of AOSD are determined by comparable pharmacokinetic exposure, extrapolation of the established efficacy of Ilaris in the treatment of SJIA, and the safety of Ilaris in the treatment of AOSD and other diseases.

Among patients receiving Ilaris treatment, common side effects reported include infections (cold and upper respiratory tract infections), abdominal pain, and injection site reactions. Ilaris’ prescription information includes warnings that may increase the risk of serious infections due to IL-1 blockade. Macrophage activation syndrome (MAS) is a known life-threatening disease that may occur in rheumatic diseases, especially in patients with Still’s disease, and should be actively treated. Treatment with immunosuppressants may increase the risk of malignant tumors. During treatment, patients are advised not to receive live vaccination.

Is it worth it to use growth hormone to build muscle and reputation?

In 1992, an empty bottle of growth hormone was found in the dressing room of the Barcelona Olympics, sparking widespread speculation about the substance’s abuse.

So far, some drugs remain difficult to detect, such as peptide hormones, including erythropoietin (EPO), insulin-like growth factor-1 (IGF-1) and growth hormones.

In fact, growth hormone (hGH, Pfizer Genotropin) is one of the preferred (banned) drugs in most sports, from sprints that focus on bursts to body-building arenas that test muscle tone.
Now, with a lot of money and manpower invested, although there are means to catch drug abusers, but more people are curious about these drugs, so many people obtain them through illegal means.

But growth hormone isn’t an expensive business. Instead, it’s part of our daily routine of exercise and rest.

The natural secretion of growth hormone

In general, athletes can adopt specific training regimens and dietary strategies to optimize their natural growth hormone (hGH) secretion.

HGH is produced in the front of the pituitary gland, a pea-sized organ located just below the brain that produces no fewer than nine different hormones.
These hormones regulate many basic physiological functions, including water and energy balance, reproductive activity, and the work of many other glands in the body.

As the name suggests, growth hormone is largely related to growth and developmental functions.
For centuries, scientists have thought of adolescence as a tipping point after which growth hormone (hGH) has no effect on growth or any other function.
The truth is, however, that growth hormone is involved in many physiological processes throughout life, including the conversion of muscle, bone and collagen, the regulation of fat metabolism and the maintenance of a healthier body later in life.

The presence of growth hormone deficiency, or GHDA, has further revealed the important function of this small hormone.
GHDA patients have relatively low muscle mass, high body fat, are prone to obesity, have an increased risk of heart disease, and are significantly less able to exercise.
Treatment for this condition usually requires regular injections of growth hormone.

The secretion of human growth hormone follows a circadian rhythm that is secreted daily in the form of 6-12 discrete pulses, the maximum of which is secreted about an hour after the onset of sleep at night (midnight for most people).
The release and inhibition of human growth hormone (hGH) is regulated by two hypothalamic hormones: growth hormone releasing hormone (GHRH) and somatostatin.
Growth hormone secretion can be triggered by many natural factors, the most powerful of which are sleep and exercise.

Most bodybuilders (should) know that exercise is a major stimulant of the natural release of growth hormone, but there’s still no evidence to go into more detail.
Many researchers believe that it may be triggered solely (or jointly) by increases in adrenaline, nitric oxide, blood lactic acid, acidity or neural activity induced by exercise.

Optimizing growth hormone production in a natural way is an optimal strategy for today’s exercisers.
This will keep more people away from any risks associated with hormone abuse.
These risks include joint pain, arthritis, abnormal heart growth, muscle weakness, increased blood lipids, impaired glucose regulation, diabetes and, of course, the consequences of drug abuse.

Relationship between diet, exercise, sleep and growth hormone

Sleep and growth factors

Because under normal circumstances, the largest hGH spikes during the day tend to occur about an hour after the start of the night’s sleep.
If sleep is poor, human growth hormone production decreases, negatively affecting health and fitness outcomes.
Good sleep is a prerequisite for optimal growth hormone production during sleep, including sleeping in a room close to darkness.

Of course, the amount of sleep you get is also important, which is about 8 hours for most people.

Diet and growth hormones

In terms of diet, because we tend to eat more carbohydrates — for example, foods with a high glycemic index (that is, high sugar content) immediately after exercise — and starchy carbohydrates most of the time.
In terms of fluid intake, many people drink carbohydrate and electrolyte (exercise) drinks before, during and after exercise.

In many cases, though, a high-carb diet may be appropriate because building muscle requires a lot of carbohydrate and water as an energy source.
But since high carbohydrate content tends to turn off human growth hormone (hGH) production, this strategy may not be the best one.
In addition, fat intake before exercise can interfere with the production of human growth hormone.

Many people take in carbohydrates immediately after training to ensure a quick replacement of the carbohydrate stores in their muscles.
However, this is not the best way to maintain the release of human growth hormone (hGH) after exercise, especially if the carbohydrate intake is high glycemic index. These foods stimulate insulin secretion, which in turn leads to a decrease in hGH.

It’s also important to drink more water during training, as dehydration also reduces exercise and promotes human growth hormone production.

What should I eat before exercise?
Taking 1.5g of arginine before exercise increases the production of human growth hormone by blocking the release of somatostatin, although some studies have shown this can cause stomach disorders.
In addition, some studies have shown that taking 2g doses of glutamine before exercise increases human growth hormone (hGH) after 90 minutes without side effects.
After exercise, you can also take in some amino acids, which can promote the secretion of human growth hormone.

Physical exercise

In terms of fitness, some studies have shown that to raise growth hormone (hGH) levels above baseline, you need to train at least 10 minutes above the lactate threshold intensity to produce the maximum amount of human growth hormone in one workout.
Hormone levels will drop gradually within an hour.
Also, training multiple times a day can produce more hGH in 24 hours.

One study looked at the effects of exercise three times a day, each with a recovery time of 1.5 or 3 hours.
They found that within 24 hours, the longer the recovery time, the higher the human growth hormone production.
Another study showed that human growth hormone peaks during sprints on an exercise bike.

Therefore, it is not long time of continuous high intensity training that can stimulate hGH secretion continuously.
If planned periodic training is used, growth hormone secretion will be better stimulated.

summary

Without growth hormone drugs, we can increase growth hormone production through exercise, diet and sleep.
In terms of exercise, which we care more about, long-term high-intensity training does not consistently stimulate growth hormone secretion. Instead, a periodic program is best.

To optimize natural growth hormone (hGH) secretion, exercise and dietary strategies are recommended as follows:

Movement.
Three times a week, each time at least 10 minutes above the lactate threshold training or multiple sprints, training rest ratio of 1:3.
Before exercise.
Eat no fat 60 minutes before, and take 2g of glutamine 60 to 90 minutes before exercise.
During exercise.
Drink plenty of fluids, such as 200 ml every 10-15 minutes during training at 18-21°C.
After exercise.
It’s best to avoid sugar for two hours after exercise, but consume around 25 grams of protein immediately after exercise in the form of a protein shake, protein bars, lean meat or eggs.
Of course, don’t forget that adequate and quality sleep not only promotes recovery, but also stimulates the production of more growth hormone.

Natural is the best.
The process of going against nature is painful, and throwing away one’s health for the sake of momentary vanity is a long way from the original purpose of fitness.
If this world really has any muscle enhancement elixir, it should be the persistence of it!